Calsyntenin 3β clstn3β
WebSep 25, 2024 · Europe PMC is an archive of life sciences journal literature. WebJul 22, 2024 · Of note, a recent discovery from Spiegelman’s group has identified calsyntenin 3β (Clstn3β), which is a thermogenic fat-specific protein located in the endoplasmic reticulum. It enhances the secretion of S100b in response to cold, which promotes sympathetic innervation and thereby improves non-shivering thermogenesis .
Calsyntenin 3β clstn3β
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Web脂肪细胞中的Calsyntenin 3β表达的缺失或获得分别减少或增强脂肪组织中的功能性交感神经支配。剔除Calsyntenin3β使得摄入高脂肪饮食的小鼠易变得肥胖。从机制上 … WebDec 7, 2024 · A adipocyte-selective product of the Clstn3 locus (CLSTN3β) present in only placental mammals facilitates the efficient use of stored triglyceride by limiting lipid droplet (LD) expansion, defining a molecular mechanism that regulates LD form and function to facilitate lipid utilization in thermogenic adipocytes. Multilocular adipocytes are a hallmark …
WebSep 25, 2024 · Activation of thermogenic adipose tissue is linked to improved metabolic outcomes in mice and humans. Dissipation of energy as heat during thermogenesis … WebJan 29, 2024 · Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways. Kim H, et al. J Biol Chem, 2024 Jul 3. PMID 32434929, Free PMC Article; CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization. Qian K, et al. Nature, 2024 Jan. PMID 36477540,
WebJul 4, 2024 · Calsyntenin 3β (CLSTN3β) is a mammal-specific membrane protein that promotes the sympathetic innervation of brown and beige adipocytes by binding to S100b, which in turn acts as a neurotrophic ... WebMoreover, Zeng et al. show that a previously unknown protein, named calsyntenin 3β (CLSTN3β), promotes the sympathetic innervation of both brown and beige adipocytes …
WebAblation of calsyntenin 3β predisposes mice on a high-fat diet to obesity. Mechanistically, calsyntenin 3β promotes endoplasmic-reticulum localization and secretion of S100b-a protein that lacks a signal peptide-from brown adipocytes. S100b stimulates neurite outgrowth from sympathetic neurons in vitro. A deficiency of S100b phenocopies ...
WebJul 8, 2024 · Recently, another study has shown that Calsyntenin 3β (Clstn3β) mediated the secretion of S100b, which posed a neurotrophic factor, enhancing the sympathetic innervations of BAT and beige iWAT . Consistent with this study, we demonstrated that Adtrp could bind to S100b and mediate the secretion of S100b, which in turn promoted … dear mother netflix reviewdear mother nature memeWebMay 1, 2024 · Here we show that a previously unknown, mammal-specific membrane protein, which we have named calsyntenin 3β (CLSTN3β), … dear mr. brody trailerWebNov 2, 2024 · Similarly, calsyntenin-3β (CLSTN3β) binds to and enhances the expression of neurotrophic factor S100b, which in turn encourages local sympathetic growth and arborization (Zeng et al., 2024). CLSTN3β silencing or upregulation reduces or enhances sympathetic innervation in BAT, respectively, and CLSTN3β ablated subjects on a high … dear mother of godWebof calsyntenin 3β, and forced expression of S100b in brown adipocytes rescues the defective sympathetic innervation that is caused by ablation of calsyntenin 3β. Our data re veal a mammal-specific mechanism of communication between ... named calsynt enin 3β (CLSTN3β ), promotes the sympathetic inner - vation of both brown and beige ... generations cremation miWebIn striking contrast to the known form of Clstn3, a completely distinct and unannotated form is expressed in BAT, which we have named Calsyntenin-3β (Clstn3β) (Fig. 1a). … generations dance company njWebDec 7, 2024 · Here, we identify calsyntenin-3β (CLSTN3β) as a critical determinant of the multilocular LD phenotype and efficient lipid use characteristic of thermogenic … generations dental hartland wi