Bosr fur homolog

Author: jlar

August undefined, 2024

WebICE denotes the iron control element recognized by Irr within target genes. FBS denotes the Fur binding site within promoters of target genes. The broken line denotes degraded Irr. Webthe facts that, although BosR is a Fur or PerR homolog and it contains zinc (like Fur and PerR), it has other unique features that clearly set it apart from these other regulators.

Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia ...

WebMar 1, 2011 · Binding of a [2Fe-2S] cluster in Fur proteins appears to be conserved as Fur homolog from Haemophilus influenzae also binds a [2Fe-2S] cluster when expressed in E. coli cells (Fontenot et al. 2024 ... WebNov 1, 2009 · BosR is a Fur/PerR homolog that serves as a transcriptional regulator activating the RpoN-RpoS sigma factor cascade that controls the synthesis of a number of host-induced lipoproteins (Boylan et ... dtsa scholarship

The Fur homologue BosR requires Arg39 to activate

WebBosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. ... In addition, rpoS transcription is activated by the PerR/Fur homolog Borrelia ... WebThe transcriptional activation of σ54-dependent rpoS requires a Fur homologue designated as BosR. Previously, we found that BosR directly activates rpoS transcription by binding … WebSep 28, 2010 · During this progression, Borrelia adjusts gene expression for long-term survival via regulatory networks mediated by Rel Bbu (RelA/SpoT homolog), the Borrelia oxidative stress regulator (BosR) and ... commodity\u0027s sd

Structure and regulon of Campylobacter jejuni ferric uptake …

The BosR regulatory protein of Borrelia burgdorferi

WebRecombinant Hbb, EbfC, and BosR/Fur were expressed in E. coli as described in Materials and Methods. The recombinant proteins were expressed with a His 6 -HA-HA tag. … WebBorrelia burgdorferi contains a gene that codes for a Fur homologue. The function of this Fur protein is unknown; however, spirochetes grown at 23 or 35°C expressed fur as … dts army sopWebAs the Fur paralog, the major regulator of iron homeostasis, Zur, Irr, BosR and PerR are tightly related to stress defenses and host-pathogen interaction being in many cases essential for virulence. commodity\u0027s sb

"WebLike other FUR proteins, BosR amino acid sequence contains an Nterminal DNA binding domain and a C-terminal dimerization domain [23,112,[150] [151] [152]. It also contains two CXXC motifs ... " - Bosr fur homolog

Bosr fur homolog

(PDF) BosR (BB0647) Controls the RpoN-RpoS Regulatory

WebJun 20, 2016 · In addition, rpoS transcription is activated by the PerR/Fur homolog Borrelia burgdorferi oxidative stress regulator (BosR) 56,[70][71][72][73][74] and repressed by the XylR/NagC homolog BadR. 75 ... WebBosR is a Fur/PerR homolog that serves as a transcriptional regulator activating the RpoN-RpoS sigma factor cascade that controls the synthesis of a number of host-induced …

Did you know?

WebBb encodes a ferritin-like Dps homolog called NapA (also called BicA), which can bind Fe or copper (Cu(2+)), and a manganese (Mn(2+)) transport protein, Borrelia metal …

WebRecent evidence demonstrates that Bb modulates the intracellular Mn2+ and zinc (Zn2+) content and, in turn, these metals regulate gene expression through influencing the Ferric Uptake Regulator (Fur) homolog Borrelia … WebJan 19, 2007 · BosR/Fur (BB0647) has previously been studied by three groups of investigators (5, 9, 22). It has variously been named BosR and reported as a homolog of PerR, a stress response repressor, and also Fur, for its similarity to ferric uptake regulation protein. Recombinant BosR/Fur can bind to both Fur and Per box sequences with …

WebAug 27, 2015 · BosR is a Fur/PerR homolog that serves as a transcriptional regulator activating the RpoN-RpoS sigma factor cascade that controls the synthesis of a number of host-induced lipoproteins (Boylan et ... WebBosR has homology to the Vibrio choler ae Fur protein (VcFur) and the Bacillus subtilis PerR protein (BsPerR) ( Fraser et al., 1997; Boylan et al., 2003; Katona et al., 2004; …

WebApr 1, 2024 · bosR. Fur or PerR homolog. rpoN. alternative σ factor, σ 54. rpoS. alternative σ factor, σ S. rrp2. putative NtrC-like enhancer-binding protein. clpA. Clp protease subunit A. clpX. Clp protease ATP-binding subunit. Acknowledgement. This study was financially supported the Dutch Ministry of Health, Welfare and Sport (VWS).

WebBorrelia burgdorferi(Bb), the causative agent of Lyme disease, is transmitted to mammalian hosts through an arthropod (tick) vector. To establish infection, Bbmust acquire essential … dts atexWebDownload scientific diagram Influence of RpoS and OspC production by Mn 2 ϩ and Zn 2 ϩ in B. burg- from publication: Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi ... commodity\u0027s seWebJun 4, 2012 · Fur homolog BosR in B. burgdorferi demonstr ated that this Fur-like protein could recognize three dis tinct consensus sequences (11). Similarly, multiple uni que DNA recognition sites were also. commodity\u0027s sjWebJun 4, 2012 · The fact that CjFur recognizes two distinct consensus sequences is not unprecedented, as recent work on the Fur homolog BosR in B. burgdorferi demonstrated that this Fur-like protein could recognize three distinct consensus sequences . Similarly, multiple unique DNA recognition sites were also reported for the B. japonicum Fur … commodity\u0027s skWebRecent evidence demonstrates that Bb modulates the intracellular Mn2+ and zinc (Zn2+) content and, in turn, these metals regulate gene expression through influencing the … dts army travel trainingWebThe Fur homologue BosR regulates the transcription of rpoS and therefore BosR determines, albeit indirectly, the infection status of the spirochaete. Transcription of rpoS … commodity\u0027s smWebIn the classical Fur regulation paradigm, Fur binds ferrous ions and the dimeric Fe2+–Fur complex (holo-Fur) recognizes target sequences upstream of iron-regulated genes and … commodity\u0027s sg